Good Read on AE's and Cholesterol

[Alter-Ego]

ORIGINALLY POSTED BY SUPERCHICKEN and stolen by tony touch from crankenstein

theres been a lot of talk on other boards about this lately, and a lot of bad information thrown out as well. i wanted to share the good info.

somone keeps posting how letrozole is the strongest and doesnt negatively affect cholesterol. this is not true. letrozole is NOT the strongest and it DOES negative affect cholesterol/lipid profile in a bad way.

aromasin(exemestane) is the best. this is why

both arimidex/ldex/anastrozole and femara/letrozole hurt your cholesterol. the way these 2 anti e's work is they inhibit the aromatase enzyme. by inhibiting the enzyme which converts testosterone to estrogen, you reduce or even come close to eliminating estrogen production. we need some estrogen to be healthy. the major drawback to this is without estrogen, your lipid profile gets ****ed.

exemestane works differently. it does not stop the body from producing estrogen. rather, it makes it so the estrogen is unable to bind to receptors by deactivating the binding enzyme. if the estrogen cannot bind, you simply will not get bloated or get gyno. the estrogen is crippled due to exemestane. however, since the estrogen is still floating around, it will not negatively affect your lipid/cholesterol profile.

anastrozole doesnt cause a rebound effect, and neither does exemestane, but letrozole does. this means after you stop the letrozole, your estrogen rebounds and goes pretty high for a while, eventually it normalizes. you can avoid this by tapering your letro dose down before stopping it, but that is a pain in the ass. higher than normal can mess many things up post cycle when you stop. since the hpta has a feedback loop is primarily controlled by estrogen, high estrogen will tell your hpta to produce less testosterone, because it thinks the high estrogen is caused by too much testosterone. this is fact. now post cycle, dont we want to raise our test levels, not lower them? of course! so rebounds are bad. if you use letro taper the dose off to zero over a couple weeks.

fyi- nolvadex(tamoxifen) is a SERM(Selective Estrogen Receptor Modulator). this means on certain tissue it can act antagonisticaly or agonistically. in the case of lipid profiles, it acts agonistically. so, running tamoxifen with your anti e's will IMPROVE your cholesterol profile even if not on cycle or using any gear or other anti e's. its just plain good for cholesterol.

one thing to keep in mind though when runing tamoxifen with letro. letro reduces blood levels of tamoxifen by over 50%. a study showed 2.5mg letro ed made nolva levels drop to 40% of what they were before adding letro. this does not mean you cant use tamoxifen with letro, it just means you need to use more, about double. 20mg of nolva will act like 8mg if running letro. so make sure you are aware of this because you will need to buy more nolva to compensate. this does not happen when mixing tamoxifen with anastrozole or exemestane, it only hppens with letro.

also, many people and myself experince a reduction of libido on letro. this doesnt happen w/ ldex or exmestane as far as i know, and in my own experience, and ive run all 3 quite a bit.

the best combo IS exemestane and tamoxifen together. your cholesterol will be as good as can be considering your on a cycle of steroids. the dose of aromasin will vary depending on the users needs and how much aromatizing gear is being taken. usually 10-25mg ed works well. run 10mg ed nolva to improve your cholesterol.

second best combo i feel is anastrozole(ldex) and tamoxifen. ldex dose ranges from usually .15mg ed to 1mg ed. run 10mg nolva ed to improve cholesterol.

thierd best is letro and nolvadex. letro doses usually range from 1-2.5mg ed. run 20mg ed nolva to improve cholesterol w/ letro.

you do not need to run nolva with any of these 3, i do recomend it though as it will improve cholesterol compared to using the anti e's alone without nolva.

so in order of strength, on a dose per dose basis(not mg per mg) aromasin is def the strognest, next is letro, and then ldex.

ive been running aromasin now for about 4 months, i wont switch back to ldex or letro. it works much better and its much healthier for cholesterol profiles.

i think we all need to stop only worrying about side effects that we can see visually. cholesterol KILLS many people around the world everyday(well not directly kills but leads to it). steroids are hrting us badly in this sense. steroids do mess our cholesterol up pretty badly, and we will pay for it later in life. now not many of us are going to stop using gear because of that, but we should at least take the proper other drugs to help minimize.

aromasin is only a little bit more expensive than ldex or letro, and its actually about the same price as many places sell ldex or letro for. but its more powerful and healthier. people spend money all the time on steroids which dont have as many side effects as some of the harsher, cheaper steroids. a few extra bucks for the proper anti e's is def money well spent.

	Nolva

	Dex

	Letro

[hooker]

I don't know about some of this...I think it's not totally correct...

[Big_Lad_R3UDE]

Great post Alter-Ego, one question for you seeing as you've found this... I'm running letro at the minute @1.25 mg eod. Now from what i've read i would need to run 20mg nolva to assist in reasonable cholesterol levels, but, i will need to taper this off and was wondering what the best approach to adopt on tapering is... Would i just increase the days between dosage or drop the dosage and increase the length of time between application? Bit confused on what's best to be honest cos i don't want to screw PCT up...

Big

	Nolva

	Letro

[Alter-Ego]

Thats the first I've ever heard of tapering letro. I used letro and found I was very lethargic while using it. It could have been the diet at the time, but when I came off the letro I definitely had more energy.

I have read about Nolvadex improving HDL cholesterol. Since Nolvadex is a weak estrogen itself it makes alot of sense.

I found this when looking for info on Aromasin.

I'm going to stick with Arimidex 1mg/daily and throw in some Nolva. A friend who competes with me is a MLT (medical lab technician) and is going to do bloodwork before and after to see how accurate this is in reference to Arimidex alone, and combined with Nolva.


Hooker, chime in, you're the expert here. What is it that does'nt jive here. Would it hurt to throw in the Nolva on top of Arimidex?

	Nolva

	Letro

	energy

[Alter-Ego]

I've also read some studies on Letro post cycle and it showed a marked increase in natural test production.

	Letro

[Squat4Life]

Tapering letro is important b/c you can have an E rebound.

	Letro

[Big_Lad_R3UDE]

Sooo confusing! I'd also read that it can increase natural test production post cycle too but again, reading what we've seen above would suggest that this is not the case as the rebound from stopping the letro would screw up the HPTA and thus causes a reduction in test production! Arrrrr! :dunno:

	Letro

[Squat4Life]

And I just read this report after my post and I still stand by it. . .

[Big_Lad_R3UDE]

Originally Posted by Squat4Life

And I just read this report after my post and I still stand by it. . .

Squat, how would you suggest the successful tapering of the letro then? Is there a science to this or is it common sense that i just don't have! :pat:

	Letro