[bordeaaj]

samax64 is absolutely right about the chronic use of ibuprofen burning a hole in your gut. Current medical literature says that 70+% of all gastrointestinal ulcers are due to the chronic overuse of NSAIDs (Nonsteroidal anti-inflammatory drugs) which include aspirin, ibuprofen (Motrin, Advil, Nuprin) and naproxen (Aleve). More commonly they can significantly raise the risk of GERD (heartburn) and increase the severity in those who have pre-existing GERD. Adding a stimulant/creatine/NO cocktail to a GI tract already sensitive due to the chronic use of NSAIDs could easily add up to some nausea. The COX2 inhibitors like Celebrex were once thought to have decreased GI side effects but not so much any more. Doesn't leave you with a lot of choice in pain medication if your knees are killing you but it might be something you could ask your doctor. There are medications like Enbrel that are specifically for rheumatoid arthritis but they tend to be very expensive. The actual medical literature on glucosamine and chondrointin, etc is sparse and not encouraging but if it seems to help it may be worth the money. Another one some bodybuilders seem to like is cissus though it didn't seem to do much for me even at higher than recommended doses.